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Exon 1 was disrupted by the insertion of a cassette containing an IRES-nls-lacZ gene, a floxed neomycin gene, and a SV40 polyadenylation signal. The absence of encoded protein in the spinal cords of homozygous mutant embryos was determined using antisera for both the amino and carboxy termini. Staining of heterozygotes showed the expression pattern of beta-galactosidase to be similar to that of the endogenous gene. (J:57340)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
