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Tyrosine codon 136 in exon 7 was changed to a phenylalanine (p.Y136F) through an A-to-T mutation. In addition to the intended mutation, a new Bgl II restriction enzyme cleavage site was introduced in the intron 3' of exon 7 to accommodate a loxP site flanked neomycin resistance gene. Founder mice were bred to deleter mice to eliminate the floxed neo cassette leaving a single loxP site in intron 7. Western blot analysis of CD4-positive T cells verified the presence of protein product in mutant animals. (J:77098)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
