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The transgene consists of a constituitive and ubiquitous cytomegalovirus promoter, an IgE intron, the rat Scnn1a (alpha ENaC; position -78 to +2149), and simian virus 40 large T antigen polyadenylation sequences. RT-PCR showed reconstitution of expression of the transgene in lung, kidney, skin, and colon tissue. Expression analysis of cardiac tissue showed that Scnn1a transcript is absent in wild-type mice and present in the transgenic mice. Transcript was undetected in liver tissue isolated from wild-type and transgenic mice. Reconstitution was additionally confirmed in lung tissue via in situ hybridization. (J:43583)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
