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An expression cassette, containing a beta-galactosidase gene adjoined to an IRES as well as a neomycin resistance gene adjoined to a MC1 promoter, was inserted 2 nucleotides downstream of the start codon. The deleted sequence extended through the end of exon 1, a total of 165 nucleotides. Beta-secretase activity was undetected in brain homogenates and extracts of cortical cell cultures derived from homozygous mutant animals. (J:77414)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
