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Exons 24 and 25, encoding amino acids in the carboxyl-terminal cytoplasmic domain (residues 1065 through 1137), were replaced with a neomycin selection cassette. Northern blot analysis of salivary gland total RNA showed normal levels of a truncated transcript. RT-PCR analysis, using probes flanking the targeted region indicated a deletion of 195 coding-nucleotides in mutant mice. (J:60671)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
