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A neomycin cassette replaced the entire coding region (exon 2 through the stop codon in exon 10). RT-PCR analaysis of kidney and liver tissue showed an absence of transcript in homozygous mutant mice. Western blot analyses of unactivated and activated plasma confirmed a lack of encoded protein in homozygous mice. Complex formation was undetectable by blotting analysis of plasma incubated with purified plasmin. (J:43244, J:54047)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
