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A construct containing a lacZ and neo fusion gene, as well as a splice-acceptor site and internal ribosome-entry site (IRES), replaced exon 2. The deleted region encoded the centromere targeting domain comprised of amino acids 29 through 64. Immunofluorescence staining using an antibody raised against the endogenous protein showed a near absence of protein, as weak signals were observed in some cells, in homozygous mutant embryos. (J:60186)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
