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An IRES-lacZ-neomycin resistance cassette replaced the most of the second exon including almost the entire DNA binding bHLH region and most of the coding region, and placed lacZ under control of endogenous transcriptional elements. RT-PCR analysis of brain did not detect transcript in homozygous mutant E18.5 embryos. Beta-galactosidase was expresssed under the control of the endogenous promoter. (J:73967)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
