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The entire coding region was replaced with a construct containing lacZ and neo. The lacZ was inserted immediately after the start codon, and thus placed under control of the endogenous promoter. Northern blot analysis revealed a lack of transcript in fibroblasts isolated from homozygous mutant embryos stimulated by IFN-gamma. An absence of expression was further confirmed by RT-PCR analysis of total embryonic RNA. The lacZ expression pattern was observed to be the same in whole mount homozygous embryos as it was in heterzygotes. (J:70667)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
