Log In|Sign Up
EN
A cassette consisting of a splice acceptor site, an internal ribosomal entry site (IRES), and a lacZ-neomycin resistance gene fusion replaced 2.6 kb of sequence encoding the ATP binding motif P-loop. The cassette was inserted downstream of the ATG-containing exon. A beta-galactosidase fusion protein is expressed from this allele. Immunoblot analysis using a polyclonal antibody against a C-terminal peptide sequence did not detect wild-type protein in brain from homozygous mutant mice. (J:73969)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
