The adjacent Cd3d and the Cd3g loci are arranged in a head-to-head fashion enabling the targeting of exon 1 from each locus with a single hygromycin cassette. Northern analysis of thymocytes isolated from homozygous mice showed an absence of transcript from both loci. Expression of the related Cd3e and Cd3z genes was observed, though at levels above and below normal, respectively. (J:76991)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129S4/SvJae
Targeted
Insertion, Intergenic deletion, Intragenic deletion
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6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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