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The gene was disrupted by insertion of a PGK-neo-lacZ cassette into exon 2 via homologous recombination, which introduces stop codons into all 3 reading frames. LoxP sites flank the PGK-neo portion of the targeting vector. Northern blot analysis of E11.5 homozygous mutant embryos did not detect gene transcripts. RT-PCR detected very low amounts of mutant transcripts thought to originate within the lacZ gene. (J:70796)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
