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The transient expression of cre recombinase within ES cells resulted in the excision of a floxed region containing a neomycin gene and the exon containing nucleotides 681-837 of the published mouse cDNA sequence deposited in GenBank as X57111. The deletion introduced a frameshift mutation. RT-PCR analysis of total RNA extracts from homozygous mutant mice showed an absence of normal transcript. Western analysis using an antibody raised against the C-terminal failed to detect protein in homozygous mutant mice. (J:51666)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
