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A PGK-neo cassette was inserted to delete a region spanning from the middle of exon 3 through exon 6. This deleted region encodes the essential homocysteine binding domain. Reduced levels of transcript were observed in extracts from the liver and kidney of heterozygous mutant mice. Enzyme activity levels in heterozygotes were found to be approximately 60% of wild-type. (J:67384)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
