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A single mutational event was used to target two genes, Bglap1 and Bglap2. A construct containing the neomycin resistance gene deleted exon 4 of Bglap1 and the entire coding region of Bglap2 by homologous recombination. A third locus in this cluster, Bglap-rs1, was left intact. Expression analysis of total RNA isolated from homozygous mutant bone showed an absence of normal transcript, while Western blot analysis revealed a lack of protein. A radioimmuno assay further confirmed the abrogation of the two loci. (J:34440)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
