A PGK-neo cassette was introduced into exon 2 via homologous recombination thus disrupting the reading frame of the gene. Absence of gene expression in homozygous mutant mice was verified by Western blot analysis of spleen and intestinal intraepithelial cells. (J:15579)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count