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A lacZ-neo fusion gene was inserted into exon 2, which encodes the basic helix-loop-helix (bHLH) domain. Northern blot analysis using a bHLH probe failed to detect transcript in total RNA isolated from homozygous mutant brain tissue. A second transcript, in which the inserted lacZ-neo gene is excised, was observed. This transcript was also found to be functionally inactive due to the lack of the bHLH domain. (J:63035)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
