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A single loxP site was inserted 5' to exon 3 and a neomycin selection cassette followed by a loxP site was inserted 3' to exon 4 through homologous recombination. The transient expression of Cre-recombinase within the targeted ES cells resulted in the excision of exons 3 and 4 and the neomycin selection gene. Northern blot analysis of total RNA isolated from the brains of homozygous animals demonstrated that no detectable transcript was expressed from this allele. (J:72940)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
