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A neomycin cassette was inserted to disrupt two exons encoding the second transmembrane domain, which is common to both splice variants, as well as a channel pore. Transcripts were not detected in the brains of homozygous mutant mice. Neither in situ hybridization nor immunostaining detected protein in the large or small dorsal root ganglion neurons of homozygous animals. (J:76712)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
