A neomycin resistance gene cassette controlled by the rabbit beta-globin promoter plus an enhancer element containing four tandem repeats of the GTIIC+GTI motif, which is active only in ES cells, was used in this allele. This cassette was inserted at the 3' end of the immunoglobulin kappa chain intron enhancer sequence (Ekappa, located between Igkj and Igkc gene segment clusters). (J:12574)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129
Targeted
Disruption caused by insertion of vector
--
--
--
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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