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EN
A neomycin resistance gene cassette controlled by the rabbit beta-globin promoter plus an enhancer element containing four tandem repeats of the GTIIC+GTI motif, which is active only in ES cells, was used in this allele. This cassette replaced the immunoglobulin kappa chain intron enhancer (Ekappa) sequence, located between Igkj and Igkc gene segment clusters, containing the octamer site, the NF-kappaB binding site, kappa E1-E3, and the kappa silencer. (J:12574)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
