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The 3' end of the gene (exons 23-27) was replaced with a PGK-HPRT minigene. Northern analysis failed to detect any intact, truncated, or fusion transcripts in homozygous mutant embryos. Western analysis failed to detect any protein in homozygous mutant embryos, when probed with antibodies against bovine DNA ligase 1. (J:76371)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
