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Disruption of the calpain small subunit gene was achieved by replacing the 3'-terminal half of exon 9 with a PGK-neo cassette. No calpain activity was detected in extracts from homozygous mutant ES cells. Although the large subunit genes were not altered and are transcribed, the resultant proteins are unstable in the absence of the small subunit. (J:74966)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
