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Exons 1-4 of this gene were replaced with a PGK-neo-poly(A) cassette via homologous recombination, resulting in the loss of the translation initiation site and F-box domain. RT-PCR verified gene expression was absent in homozygous mutant animals and immunoprecipitation failed to detect full length or truncated protein product. (J:62130)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
