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The gene was disrupted by replacing sequences encoding the HMG box with a LoxP-neo-LacZ cassette via homologous recombination. RT-PCR analysis of mutant embryos confirmed transcripts of the HMG coding region were absent although transcripts of the trans-activating domain downstream of the LoxP-neo-LacZ cassette were present. (J:66010)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
