Insertion of a neomycin resistance cassette into the E47-specific HLH exon disrupted the gene. Western blot analyses of thymus from homozygous mutant mice did not detect E47 protein, and detected E12 protein at levels that were at least 5-fold lower than wild-type. (J:38711)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count