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The editing site complementary sequence (ECS) in intron 11 was replaced with a loxP-flanked neomycin resistance cassette. The neomycin cassette was removed by transient Cre expression in ES cells prior to the production of chimeric mice, leaving a single loxP site in place of the ECS. RT-PCR analysis on RNA derived from brains of homozygous mice demonstrated that unedited transcripts were produced from this allele. (J:30145)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
