A lacZ-neomycin fusion gene was inserted in-frame immediately downstream of the initiation codon. Western blot analysis on doubly targeted ES cells confirmed that no ETL1 protein was expressed from this allele; however, beta-galactosidase was expressed under the control of the endogenous promoter. (J:56661)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count