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A neomycin resistance cassette replaced a genomic fragment containing exons 3 and 4, which encode three disulfide loops, the heparin binding region and the transmembrane domain of the precursor protein. Northern blot analysis on RNA derived from stomach and skin of homozygous mice demonstrated that a smaller transcript is produced from this allele. RT-PCR and sequencing analysis confirmed the loss of coding sequences from this transcript. (J:54980)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
