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This transgene expresses Cre recombinase under the control of the collagen II (Col2a1) promoter, which directs expression in all cartilagenous structures at E12.5, as well as the facial mesenchyme and the CNS. At E13.5, Cre-recombinase activity is detected in the skeletal structures of the developing appendicular, axial and cranial skeleton, such as long bones of limbs, ribs, vertebrae and skull base, as well as in the epithelial cells of kidney, pancreas, lungs, intestine and ovary. (J:73071, J:140779)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
