A neomycin selection cassette was inserted into exon 8. Northern blot analysis on RNA derived from various tissues of homozygous mice demonstrated that aberrant transcripts were produced from this allele. Western blot analysis on lysates derived from brain, heart, pancreas and skeletal muscle confirmed that no detectable protein is made from this allele. (J:69979)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
Insertion
--
1
--
9

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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