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A genomic fragment containing exons 1, 2 and 3 was replaced with a neomycin selection cassette. Northern blot analysis on RNA derived from LPS-induced splenocytes of homozygous mice demonstrated that no detectable transcript was produced from this allele. ELISA assays confirmed that no detectable protein was produced in homozygous mice. (J:17249, J:47064)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
