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DNA sequences encoding the entire open reading frame of the gene were replaced with a neomycin selection cassette. RT-PCR analysis on RNA derived from brain, kidney, liver, lung, testis and induced peritoneal macrophages demonstrated that no detectable transcript is produced from this allele. Immunocytochemistry and flow cytometry experiments confirmed that no detectable protein is expressed from this allele in induced peritoneal macrophages derived from homozygous mice. (J:68807)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
