A gap-repair vector was used to induce a tandem duplication of the gene. Guanylate cyclase activity assays demonstrated a correlation of increased activity to gene dosage in heterozygous and homozygous mice. (J:46175)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count