A PGK-neomycin resistance cassette replaced about 5 kb of sequence including exons 3-7, which encode the second LIM domain, the homeodomain, and most of the carboxy-terminal region. RT-PCR analysis did not detect transcript from the region encoding the homeodomain in homozygous mutant 10 dpc embryos. (J:47316)
Basic Information
Insertion, Intragenic deletion
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count