A neomycin selection cassette was inserted in reverse transcriptional orientation in front of the coding sequence for the first transmembrane domain of the encoded protein. Competitive binding assays demonstrated a reduction in specific binding of labeled ligand to peritoneal exudate cells derived from homozygous mice. (J:44561)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count