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The gene was disrupted by the insertion of the gene trap vector IRES Beta-geo into intron 1. Northern blot analysis on RNA derived from E12.5 embryonic fibroblasts from homozygous mice demonstrated that no detectable transcript was produced from this allele, and western blot analysis on protein derived from E12.5 embryonic fibroblasts revealed that no detectable wild-type protein was made. (J:74249)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
