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Insertion of an IRES-neomycin resistance cassette into exon 13 introduced a Tyr508Phe point mutation. Northern blot analysis of bone marrow macrophages detected expression of a truncated message in homozygous mutant mice. Immunoblot analysis detected reduced levels of protein in bone marrow macrophages from homozygous mutant mice. (J:72269)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
