Bcl2l11^tm1.1Jad

Insertion of a floxed PGK-neomycin resistance cassette removed the first three coding exons and placed a lacZ gene under the control of the endogenous promoter. This allele is a derivative of Bcl2l11tm1Jad in which subsequent Cre-mediated recombination in vivo removed the neo cassette in the germline. The final allele has a single loxP site in place of the three exons. Intense beta-galactosidase staining was detected in the mesenchyme of the metanephric cap of E13.5 heterozygous embryos. (J:73316)