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Insertion of a floxed PGK-neomycin resistance cassette removed the first three coding exons and placed a lacZ gene under the control of the endogenous promoter. This allele is a derivative of Bcl2l11tm1Jad in which subsequent Cre-mediated recombination in vivo removed the neo cassette in the germline. The final allele has a single loxP site in place of the three exons. Intense beta-galactosidase staining was detected in the mesenchyme of the metanephric cap of E13.5 heterozygous embryos. (J:73316)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
