The gene trap was inserted between exons 1 and 2, resulting in a fusion transcript of exon 1 fused to the gene trap vector sequence. The vector, pGT2TMpfs, contained part of En2, the transmembrane domain of CD4, Beta-geo, IRES, PLAP and pA elements. Northern blot against a cDNA probe for the 3' end of Ext1 showed no 3' mRNA present in mutants. This allele is reported to be a hypomorph (J:92212). (J:91757)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Gene trapped
Insertion of gene trap vector
Recessive
1
5
8

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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