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A hygromycin selection cassette replaced a genomic fragment containing exon 4, which encodes part of the active site of the enzyme. Western blot analysis of thymus, liver and brain extracts confirmed that the protein was not detectable in homozygous mice. Activity assays demonstrated that no functional protein was made from this allele in homozygous mice. (J:26731)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
