Chrna7^tm2Bay

Point mutations were introduced into exon 8 that altered codon 250 from one encoding leucine to one encoding threonine. Additional mutations in intron 7 created a new restriction site. A loxP-flanked neomycin and thymidine kinase selection cassette was also inserted in intron 9, but was subsequently removed by Cre mediated recombination in ES cells prior to the production of chimeric mice. (J:61536)