Myo7a^26SB

A T-to-A transversion mutation is predicted to result in a phenylalanine to isoleucine change at position 1800 in the encoded protein. This mutation is predicted to lie within the tail domain of the protein. Northern blot analysis indicated that mRNA expression, size, and stability were unaffected. Immunoblot analysis showed that 46% of the normal level of the protein was expressed in testis and 18% of the normal level in kidney. (J:49926)