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Ptprj has been identified as the gene underlying the susceptibility to colon cancer phenotype. Mouse strains STS/A and BALB/cHea carry alleles of Scc1 conferring cancer susceptibility and resistance, respectively. Five amino acid substitutions have been identified between the strains, 2 conservative and 2 nonconservative substitutions in the extracellular domain and 1 conservative substitution in the intracellular domain. The STS/A haplotype also contains an insertion of 17 bp within intron 4. (J:77487)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
