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A genomic fragment containing the coding region of exon 1 and part of intron 1 was replaced by a neomycin resistance cassette. Nothern blot and RT-PCR analysis demonstrated that an aberrant transcript is produced from this allele in total brain RNA from homozygous mice, but western blot analysis confirmed the absence of the protein in extracts derived from brains of homozygous mice. (J:55338)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
