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A neomycin resistance cassette replaced an ~8kb segment of the gene, comprising 2.5kb of the putative promoter, the first exon containing the ATG translational start codon, and genomic sequences containing ~50% of the coding region of the gene. Northern and Western blots of brain tissue from homozygous mutant mice showed no detectable transcript and protein, respectively. (J:65196)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
