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A neomycin resistance cassette replaced exon 3, which encodes the first Ig domain contained only in alpha isoforms of the protein. Western blot analysis demonstrated that the alpha isoforms of the protein were not expressed in E9.5 mutant embryos. RT-PCR analysis showed that an increased level of expression of "b" isoform transcripts may partially compensate for loss of alpha isoform expression, and the expression of the "c" isoform is apparently unaffected. (J:54222)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
