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A loxP flanked neomycin cassette was inserted into intron 15, and point mutations were introduced into the sequences encoding the one of the autophosphorylation sites and the PLCgamma binding site that altered the corresponding amino acids from tyrosine to phenylalanine. This is a hypomorphic allele. (J:49154)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
