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A promoterless IRES-LacZ-neomycin resistance cassette containing a 5' En-2 intron and splice acceptor site replaced exons 17-21. Northern analysis of homozygous mutant E12.5 embryos using an exon 15 probe detected a 12.5kb fusion transcript, and did not detect the wild-type transcript. Western analysis using an anti-beta-galactosidase antibody detected the predicted 146kDa beta-galactosidase-neomycin fusion protein in homozygous mutant embryos. (J:72238)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
