Pcdh15^av-Tg2742Rpw

A construct consisting of a human beta-actin promoter driving expression of a rat lectin cDNA was injected into fertilized eggs. The construct integrated in multiple tandem copies into the coding region of the Pcdh15 gene, disupting the coding seqence for the fourth cdh domain. Truncated transcripts are produced from this allele that are smaller than normal size due to the SV40 poly(A) site that is present in the transgene. (J:66738)